Week 15 College football picks, schedule: Predictions against the spread, odds for top 25 games in Week 15
A closer look at the top games on the slate in Week 15 college football picks of the 2020 season
Week 15 college football picks: The final week of the 2020 regular season is upon us, but despite that, there have still been numerous cancellations affecting major games scheduled for Saturday.

GAINESVILLE, FL – OCTOBER 31: Kyle Trask #11 of the Florida Gators throws the ball against the Missouri Tigers at Ben Hill Griffin Stadium on October 31, 2020 in Gainesville, Florida.
No. 4 Ohio State and No. 11 Oklahoma are among teams who were set to play but will not take the field, and the ACC ensured No. 2 Notre Dame and No. 3 Clemson are not playing in order to preserve their health for the ACC Championship Game next week.
The SEC did not follow that lead. No. 1 Alabama and No. 6 Florida are among the ranked teams in action Saturday. Both are favorites of three touchdowns or more in their respective games as the Crimson Tide and Gators attempt to stay healthy ahead of their showdown in the SEC Championship Game next week.
Will the College Football Playoff Rankings look any different before the weekend is out? We’ll find out based on the results of these marquee games. While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff on Saturday to the final whistle. Let’s take a look at our expert picks for Week 15.
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Odds via William Hill Sportsbook | All times Eastern
No. 9 Georgia at No. 25 Missouri
Missouri is playing with a ton of confidence after picking up its third straight win last week. Though running the ball will be tough against this Georgia defense, Connor Bazelak should be able to have enough success against the Bulldogs secondary to keep the Tigers within striking distance. Motivation could also be an issue for a Georgia team that is nearing the end of its season without championships on the line. Pick: Missouri (+13) — David Cobb
No. 1 Alabama at Arkansas
I feel like a broken record, but it’s nearly impossible to consistently pick Alabama games when it can dial up any score that it wants. You have to factor in the situation when looking at this 31.5-point spread. Will coach Nick Saban really want to leave his starters out there knowing that the SEC Championship Game vs. Florida is looming next week? I doubt it. That coupled with the challenge of preparing for two quarterbacks will be enough to get the Hogs the cover. Pick: Arkansas (+31.5) — Barrett Sallee
To make your winning Week 15 College football picks click here!